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Practical implications

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Given the limited support for the efficacy of micronutrient supplements in preventing disease and the potential concerns about adverse effects, it is essential to read labels and select supplements that contain equal to or less than the recommended amounts of specific nutrients (e.g. 100% of recommendations for general health), which are well below the amounts of concern for beta‐carotene and vitamin A. Even the potential benefits of vitamin E are within the range in MVM supplements (100–150% of recommendations for general health). The potential benefits (and risks) of folic acid supplementation might not be seen with typical MVM supplements, and clinical trials of folic acid are often investigated in combination with other nutrients (vitamin B6 and vitamin B12). Additional research is needed to confirm the beneficial effects observed for vitamin E, folic acid, and calcium supplements in recent meta‐analyses.37

Pathy's Principles and Practice of Geriatric Medicine

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