Читать книгу DNA Origami - Группа авторов - Страница 38

DNA origami can be fitted and made compatible with solid materials made by semiconductor processing. Triangular origami binding sites on a surface were fabricated by electron beam lithography and dry etching. For the alignment of triangular origami, their binding sites were fabricated on a SiO₂ surface passivated with trimethylsilane (TMS) or origami binding sites on diamond‐like carbon (DLC). Using this method, triangular origami was selectively fitted to the binding sites depending on the size of the binding sites [96]. The hydrophilicity of the surface of the binding sites passivated with TMS is considered to be a driving force for binding. Using various shapes of binding sites on the surface, multiple origami triangles were selectively attached. Using a similar method, gold particles bound to the three vertices of a DNA triangle were successfully aligned to the origami binding sites with controlled orientation and arrangement [96, 97].

Using the techniques developed in these studies, functional molecules and nanoparticles can be selectively placed at specific positions of DNA origami in a programmed fashion. In addition, DNA origami can be integrated with top‐down nanotechnology. These methods could be applied for creating nanoscale devices with novel functionality when the functional origami is precisely integrated on the fabricated surface.