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DNA origami technology enables the creation of robust 3D structures, which can perform various mechanical movements [98, 99]. A dynamic DNA origami that changes 3D structure in response to external stimuli such as salt concentration and temperature was developed. In the design, shape fitting and π–π stacking interactions between the base pairs were utilized. As shown in (Figure 1.13a), the DNA origami consists of two shape‐complementary rods that can rotate around the pivot, and the opened X‐shaped structure closes into a closed rod shape depending on the salt concentration [100]. By detecting open and close states by fluorescence, the structure operated more than 1000 open/close cycles without breaking by heating and cooling. The performance and robustness as a mechanical molecular device were excellent. Furthermore, a movable grid assembly at the micrometer scale was constructed by further assembling the dynamic DNA origami. In combination with these mobile parts, as a demonstration, a nanoscale “human‐shaped robot” was also constructed, that can open and close the arms by controlling the salt concentration (Figure 1.13b). Using DNA origami in this way, it is possible to create designable self‐assembled materials that can be driven in response to various external stimuli.