Читать книгу DNA Origami - Группа авторов - Страница 50

The emergence of DNA origami technology has enabled the construction of various 2D and 3D nanostructures and a wide variety of applications. Since DNA origami was first reported in 2006, this technology has relegalized target‐oriented research in the field nanotechnology related to computer science, chemistry, physics, materials science, biology, and medicine. Compared with the use of small DNA assemblies, the DNA origami method improves the flexibility of the structure design and reduces experimental uncertainties. For chemical applications, various methods have been developed to construct synthetic nanosystems and functionalized nanodevices. For physical applications, various single‐molecule studies have been conducted at the nanoscale using DNA origami. For biological applications, cellular and tumor‐targeting studies have been performed and progressed using dynamic DNA origami with various target functions. These achievements show that it is possible to assemble functional DNA origamis as a module to express higher level functionalities in a programmed fashion. Functionalized DNA origami has already been combined with top‐down nanotechnology including semiconductor processing techniques. This technology also opens a way to express the complex functionality of the programmed organization of many different modules seen in living systems.