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Estrogen, progesterone, and testosterone are surprisingly busy in your brain, interacting intimately with all your neurotransmitters, including the cats. When estrogen in particular falls too low, it can trigger the blahs by failing to stimulate the cats. The same is true of low testosterone. In both the male and the female “pause,” and in the hormonally unstable peri-menopausal years leading up to female menopause, both these hormone levels can drop quite low. If you’re going through any of these hormonally unpredictable phases and experiencing mood problems, you should consider thorough sex hormone testing. I believe that everyone over 40 should have the best information possible on their sex hormone levels, especially if they have troubling symptoms like severe PMS or prostate worries, in addition to mood changes. Any serious premenopausal symptom (such as endometriosis or irregular periods) warrants the same investigation. The best sex hormone testing we’ve found, by far, is saliva testing. You can find all the details on how to do an accurate exploration of your sex hormone levels in the “Sex Hormone Tool Kit,” page 329.