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These drugs (e.g. losartan, valsartan, candesartan) are similar to the ACE inhibitors except that instead of inhibiting angiotensin-converting enzyme, they block angiotensin-II to produce similar effects. This dilates blood vessels, stimulates kidney function and may also have a direct action on the brain to reduce drinking and increase urine output. At present, they are mainly used in people who develop a persistent dry cough as a troublesome side-effect of the ACE inhibitors as these particular drugs do not produce this problem.