Читать книгу Routes to Essential Medicines - Peter J. Harrington - Страница 67

The selective reduction of one nitro group in a 2,4‐dinitroaniline is a key step in the synthesis of bendamustine. (How selective is this reduction?) Draw the structures of the retrosynthetic analysis of an alternative route to bendamustine which is based on reduction of both nitro groups of a dinitroaromatic in the same step. List the pros and cons for both routes and select one route as the preferred route.