Читать книгу Routes to Essential Medicines - Peter J. Harrington - Страница 79

Cardiovascular Medicines/Antiarrhythmic Medicines

Cardiovascular Medicines/Medicines Used in Heart Failure

A β–amino alcohol is often formed by ring‐opening an epoxide with an amine.

Discussion. Bisoprolol is a 1 : 1 mixture of (R)‐ and (S)‐enantiomers. The β–amino alcohol is formed in the final step by ring‐opening of the epoxide with isopropylamine. The epoxide is formed from the chlorohydrin. The chlorohydrin is formed by the ring‐opening of epichlorohydrin by the phenol. The benzyl ether is formed by the reaction of 4‐hydroxybenzyl alcohol with 2‐isopropoxyethanol.