Читать книгу Routes to Essential Medicines - Peter J. Harrington - Страница 71

Dermatological Medicines/Scabicides and Pediculicides

When a target molecule is accessible by more than one efficient route, the preferred route is likely to have the lowest raw material costs.

Discussion. Disconnection of the C─O bond suggests benzyl benzoate is manufactured from benzyl alcohol and the acid chloride, anhydride, ester, or carboxylic acid. Methyl benzoate, a byproduct from the manufacture of polyethylene terephthalate (PET or PETE) is used in one manufacturing route. Benzaldehyde is converted to benzyl benzoate in an alternative manufacturing route (Claisen–Tishchenko Reaction).