Читать книгу Routes to Essential Medicines - Peter J. Harrington - Страница 68

Anti‐Infective Medicines/Antiprotozoal Medicines/Antitrypanosomal Medicines/American Trypanosomiasis

A 2‐nitroimidazole is often formed from a 2‐aminoimidazole via the diazonium salt.

Discussion. The amide is formed in the final step by reaction of the ethyl ester with benzylamine. Ethyl 2‐nitroimidazole‐1‐ylacetate is formed from ethyl bromoacetate by bromide displacement by 2‐nitroimidazole. 2‐Nitroimidazole is formed from 2‐aminoimidazole via the diazonium salt. 2‐Aminoimidazole is formed from O‐methylisourea and 2,2‐dimethoxyethanamine. O‐Methylisourea is formed from cyanamide and methanol.