Читать книгу Essential Endocrinology and Diabetes - Richard I. G. Holt - Страница 17
Box 1.3 The ‘Endocrine Postulates’: Edward Doisy, St Louis University School of Medicine, USA, 1936
ОглавлениеThe gland must secrete a substance (an ‘internal secretion’)
Methods of detecting the secretion must be available
The purified substance (the hormone) must be recoverable from gland extracts
The hormone must be capable of isolation for its structure to be determined and for synthesis
To this could be added:
The hormone must act on specific target cells via a receptor such that excess or deficiency causes a specific phenotype