Читать книгу Handbook of Diabetes - Rudy Bilous - Страница 45

Wheat gluten is a potent diabetogen in animal models of type 1 diabetes (BB rats and NOD mice; see below), and 5–10% of patients with type 1 diabetes have gluten‐sensitive enteropathy (coeliac disease). Recent studies have demonstrated that patients with type 1 diabetes and coeliac disease share disease‐specific alleles. Wheat may induce subclinical gut inflammation and enhanced gut permeability to lumen antigens in some patients with type 1 diabetes, which may lead to a breakdown in tolerance for dietary proteins. Other possible diabetogenic factors in diet include N–nitroso compounds, speculatively implicated in Icelandic smoked meat, which was a common dietary constituent in winter months.