Читать книгу Handbook of Diabetes - Rudy Bilous - Страница 47

Spontaneous diabetes that resembles type 1 diabetes in humans occurs in some animals, notably the BioBreeding (BB) rat and the non‐obese diabetic (NOD) mouse. These ‘animal models’ have many of the same characteristics as human autoimmune diabetes, including a genetic predisposition, MHC association, insulitis, circulating islet cell surface and GAD autoantibodies, a long prediabetic period that precedes overt hyperglycaemia and environmental factors that trigger or accelerate the appearance of diabetes, such as wheat and cow’s milk proteins. Many hypotheses of the causes of type 1 diabetes have been developed and tested in these animals.