Читать книгу Handbook of Diabetes - Rudy Bilous - Страница 49

The observed increase in non‐autoimmune type 1 diabetes and its links to type 2 diabetes susceptibility genes, as well as the increasing rates of obesity in children, has led to the concept of increasing insulin resistance as a cause of β cell loss. It is generally believed that β cell loss is a feature of ageing, and obesity related insulin resistance could accelerate this loss through apoptosis and be partly responsible for the increasing incidence of both type 1 and type 2 diabetes. Much of the supportive evidence remains cross sectional rather than prospective, however.