Читать книгу Snyder and Champness Molecular Genetics of Bacteria - Tina M. Henkin - Страница 117

The antibiotic hydroxyurea inhibits the enzyme ribonucleotide reductase, which is required for the synthesis of all four precursors of DNA synthesis (Figure 1.5). The ribonucleotide reductase catalyzes the synthesis of the deoxynucleoside diphosphates dCDP, dGDP, dADP, and dUDP from the ribonucleoside diphosphates, an essential step in deoxynucleoside triphosphate synthesis. Mutants resistant to hydroxyurea have an altered ribonucleotide reductase.