Читать книгу Snyder and Champness Molecular Genetics of Bacteria - Tina M. Henkin - Страница 118

5-Fluorodeoxyuridine and the related 5-fluorouracil have monophosphate forms resembling dUMP, the substrate for thymidylate synthetase. By competing with the natural substrate for this enzyme, they inhibit the synthesis of deoxythymidine monophosphate. Mutants resistant to these compounds have an altered thymidylate synthetase. These are useful antibiotics for the treatment of fungal, as well as bacterial, infections.