Читать книгу Snyder and Champness Molecular Genetics of Bacteria - Tina M. Henkin - Страница 121

Mitomycin C blocks DNA synthesis by cross-linking the guanine bases in DNA to each other. Sometimes the cross-linked bases are in opposing strands. If the two strands are attached to each other, they cannot be separated during replication. Even one cross-link in DNA that is not repaired prevents replication of the chromosome. This antibiotic is also a useful antitumor drug, probably for the same reason. DNA cross-linking also affects RNA transcription.