Читать книгу Snyder and Champness Molecular Genetics of Bacteria - Tina M. Henkin - Страница 154

Some antibiotics that inhibit transcription do so by inhibiting the synthesis of the rNTPs. An example is azaserine, which inhibits purine biosynthesis. Azaserine and other antibiotics that block the synthesis of the ribonucleotides are usually not specific to transcription, since the ribonucleotides, including ATP and GTP, have many other uses in the cell. This lack of specificity limits the usefulness of these antibiotics for studying transcription, although some of them have other uses.