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BOX 2.3 Antibiotic Inhibitors of Translation

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The translation apparatus of bacteria is a particularly tempting target for antibacterial drugs because it is somewhat different from the eukaryotic translation apparatus and is highly conserved among bacteria. Antibiotics that inhibit translation are among the most useful of all the antibiotics and are listed in the table, which also lists their targets and sources. Toxicity in some cases may result from the similarity of bacterial and mitochondrial ribosomes. Some of these antibiotics are also very useful in combating fungal diseases and in cancer chemotherapy.

Snyder and Champness Molecular Genetics of Bacteria

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