Читать книгу Snyder and Champness Molecular Genetics of Bacteria - Tina M. Henkin - Страница 156

Streptolydigin also binds to the β subunit of the RNA polymerase of bacteria but can block RNA synthesis after it is under way. It has a weaker affinity for RNA polymerase than does rifampin, so it blocks transcription only when added at higher concentrations, which limits its usefulness. Bicyclomycin targets the transcription terminator protein ρ and prevents ρ-dependent transcription termination (but not factor-independent transcription termination). Use of bicyclomycin as an antibiotic depends on the importance of ρ-dependent transcription termination in the target organism.