Читать книгу Snyder and Champness Molecular Genetics of Bacteria - Tina M. Henkin - Страница 157

Actinomycin D and bleomycin block transcription by binding to the DNA. After bleomycin binds, it also nicks the DNA. While such drugs have been useful for studying transcription in bacteria, they are not very useful in antibacterial therapy because they are not specific to bacteria and are very toxic to humans and animals. They are, however, used in antitumor therapy.