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Semiconservative DNA Replication

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In 1953, James Watson and Francis Crick published their structure of DNA. One of the predictions of this model is that DNA replicates by a semiconservative mechanism, in which specific pairing occurs between the bases in the old and the new DNA strands, thus essentially explaining heredity. In 1958, Matthew Meselson and Frank Stahl used bacteria to confirm that DNA replicates by this semiconservative mechanism.

Snyder and Champness Molecular Genetics of Bacteria

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