Читать книгу Transporters and Drug-Metabolizing Enzymes in Drug Toxicity - Albert P. Li - Страница 69

The current knowledge on nefazodone metabolism suggest that increased metabolic activation (e.g. enhanced CYP3A4 activity due to environmental and genetic factors) as well as compromised detoxification pathways (e.g. decreased glutathione S‐transferase (GST) activity and depletion of GSH by environmental agents) are likely risk factors of nefazodone hepatotoxicity. As nefazodone hepatotoxicity may be related to bile salt accumulation via BSEP inhibition, environmental, and genetic factors leading to compromised BSEP functions may also be a risk factor for its hepatotoxicity.