Читать книгу Transporters and Drug-Metabolizing Enzymes in Drug Toxicity - Albert P. Li - Страница 72

FXR regulates transporter‐mediated efflux via upregulation of BSEP [134], OST‐a, and OST‐b [135, 136]. OCA, as an agonist of FXR, has been shown to increase the mRNA levels of the bile salt export pump (BSEP), and the basolateral efflux heterodimer transporters, organic solute transporter alpha (OSTalpha) and OSTbeta in primary cultured human hepatocytes [148]. However, as of this writing, there the roles of transporters in OCA toxicity, if any, is not yet defined.