Читать книгу Transporters and Drug-Metabolizing Enzymes in Drug Toxicity - Albert P. Li - Страница 85

High CYP1A2 activities in combination with low GSH levels could be risk factors for tacrine hepatotoxicity. The caffeine breath test, a clinical bioassay for CYP1A2 activity in patients, however, was not successful in the identification of patients with high susceptibility to tacrine hepatotoxicity [180]. On the other hand, there appeared to be correlation between GST polymorphism and susceptibility to tacrine hepatotoxicity [181, 182]. For instance, multivariate Cox hazards model showed that the GST M1‐T1 null genotype was an independent risk factor of tacrine hepatotoxicity [181].