Читать книгу Transporters and Drug-Metabolizing Enzymes in Drug Toxicity - Albert P. Li - Страница 84

As of this writing, there is no evidence that tacrine hepatotoxicity is associated with its interaction with transporters. However, results with rats show that tacrine distribution into rat brains across the blood brain barrier is a function of transporter‐mediated uptake involving organic cation transporters [179].