Читать книгу Transporters and Drug-Metabolizing Enzymes in Drug Toxicity - Albert P. Li - Страница 73

As the mechanism of OCA toxicity is not yet elucidated, risk factors are not yet defined. Based on clinical findings, patients with preexisting liver cirrhosis may have a higher risk toward OCA hepatotoxicity. This “risk factor”, however, is yet to be confirmed (https://livertox.nih.gov/ObeticholicAcid.htm).