Читать книгу Transporters and Drug-Metabolizing Enzymes in Drug Toxicity - Albert P. Li - Страница 77

The major risk factors associated with Sitaxentan are likely to be environmental and genetic factors that would lead to enhanced formation of the toxic reactive metabolites (e.g. elevation of CYP3A4 activity due to exposure to inducers) or compromised detoxification pathways (e.g. decreased cellular GSH contents due to co‐exposure to GSH depleting agents).