Читать книгу Clinical Pharmacology and Therapeutics - Группа авторов - Страница 67

The more severe forms of liver disease are accompanied by poorly understood derangements of brain function that ultimately result in the syndrome of hepatic encephalopathy. However, even before encephalopathy develops, the brain is extremely sensitive to the effects of centrally acting drugs and a state of coma can result from administering normal doses of opiates or benzodiazepines to such patients.