Читать книгу Clinical Pharmacology and Therapeutics - Группа авторов - Страница 65

These are drugs which the liver metabolises at a very high rate. Their bioavailability is low and their clearance is dependent mainly upon the rate of drug delivery to the enzyme systems. The clearance of these drugs is therefore relatively sensitive to factors that can influence hepatic blood flow, such as congestive cardiac failure, and relatively insensitive to small changes in enzyme activity or protein binding. Examples include labetalol, lidocaine, metoprolol, morphine, propranolol, pethidine, nortriptyline and verapamil.