Читать книгу Clinical Pharmacology and Therapeutics - Группа авторов - Страница 59

There are several examples of increased drug sensitivity in patients with renal failure. Opiates, barbiturates, phenothiazines and benzodiazepines all show greater effects on the nervous system in patients with renal failure than in those with normal renal function. The reasons are not known, but increased meningeal permeability is one possible explanation.

Various antihypertensive drugs have a greater postural effect in renal failure. Again the reasons are not clear, but changes in fluid balance and autonomic dysfunction may be partly responsible.