Читать книгу Clinical Pharmacology and Therapeutics - Группа авторов - Страница 50

Mrs D.L., a 38‐year‐old woman who weighs 55 kg, was prescribed phenytoin at a dose of 300 mg/day (5.5 mg/kg/day) after carbamazepine failed to control her epilepsy. She attended the outpatient clinic 3 weeks later and her 24‐hour post‐dose trough phenytoin concentration was 6 mg/L (24 μmol/L). As her seizures were not well controlled, her dose was increased to 350 mg/day (6.4 mg/kg/day). She presented to her general practitioner 2 weeks later complaining of fatigue and difficulty in walking properly. Her trough phenytoin concentration was 28 mg/L (112 mol/L).