Читать книгу Clinical Pharmacology and Therapeutics - Группа авторов - Страница 46

Mr J.L., a 64‐year‐old man who weighs 80 kg and has an estimated creatinine clearance of 35 mL/min, requires gentamicin therapy for a suspected Gram‐negative infection. The aim is to achieve a peak concentration around 8 mg/L and a trough around 1 mg/L.

Table 1.5 Predicted steady‐state digoxin concentrations for clinical scenario.

Dose (μg)	Cssaverage (μg/L)	Csstrough (μg/L)
250	3.0	2.4
187.5	2.2	1.8
125	1.5	1.2
62.5	0.75	0.6