Читать книгу Clinical Pharmacology and Therapeutics - Группа авторов - Страница 62
Influence of liver disease
Оглавление
Impaired liver function can influence the response to treatment
1 Altered pharmacokinetics:Increased bioavailability resulting from reduced first‐pass metabolism or, potentially, decreased first‐pass activation of pro‐drugsDecreased protein binding
2 Altered drug effect
3 Worsening of metabolic state
