Читать книгу Clinical Pharmacology and Therapeutics - Группа авторов - Страница 58

The hepatic metabolism of some drugs (e.g. nicardipine, propranolol) may be decreased in patients with renal failure. The reasons for this are not clear, but may indicate the presence of a metabolic inhibitor in uraemic plasma because regular haemodialysis appears to normalise the clearance of these compounds.