Читать книгу Clinical Pharmacology and Therapeutics - Группа авторов - Страница 82

Age‐related changes in body composition, protein binding and organ blood flow can all have significant effects on drug disposition. Ageing increases the composition of body fat to water. Therefore, initial drug concentrations of water‐soluble drugs such as digoxin and cimetidine can be increased. Lipid‐soluble drugs such as diazepam will have an increased volume of distribution, lower plasma concentration and prolongation of the elimination half‐life resulting in a prolonged effect. Plasma protein–drug binding changes little with age.