Читать книгу Clinical Pharmacology and Therapeutics - Группа авторов - Страница 81

Ageing results in increased gastric pH, delayed gastric emptying, decreased intestinal motility and reduced splanchnic blood flow. However, the extent to which these factors alter bioavailability of a drug is thought to be negligible. For example, the rate of absorption of digoxin is slower in the elderly but the overall bioavailability remains the same.