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Hepatotoxic drugs

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Where an acceptable alternative exists, it is wise to avoid drugs that can cause liver damage (Table 1.7), e.g. sulphonamides or rifampicin, and repeated exposure to halothane anaesthesia.

Table 1.7 Drugs that can cause liver damage.

Hepatitis
Halothane (repeated exposure)
Isoniazid
Rifampicin
Methyldopa
Phenelzine
Trimipramine
Desipramine
Carbimazepine
Trasidone
Propylthiouracil
Augmentin
Erythromycin
Nitrofurantoin
Chloroguanide
Tienilic acid
Dihydralazine
Azothiaprine
Sulfasalazine (sulphasalazine)
Naproxen
Amiodarone
Cholestasis with mild hepatic component
Phenothiazines
Carbamazepine
Tricyclic antidepressants
Non‐steroidal anti‐inflammatory drugs (especially phenylbutazone)
Rifampicin, ethambutol, pyrazinamide
Sulphonylureas, trimethoprim
Sulphonamides, ampicillin, nitrofurantoin, erythromycin estolate
Oral contraceptives (stasis without hepatitis)
Cirrhosis
Methotrexate
Clinical Pharmacology and Therapeutics

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