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Hepatotoxic drugs
ОглавлениеWhere an acceptable alternative exists, it is wise to avoid drugs that can cause liver damage (Table 1.7), e.g. sulphonamides or rifampicin, and repeated exposure to halothane anaesthesia.
Table 1.7 Drugs that can cause liver damage.
Hepatitis |
Halothane (repeated exposure) |
Isoniazid |
Rifampicin |
Methyldopa |
Phenelzine |
Trimipramine |
Desipramine |
Carbimazepine |
Trasidone |
Propylthiouracil |
Augmentin |
Erythromycin |
Nitrofurantoin |
Chloroguanide |
Tienilic acid |
Dihydralazine |
Azothiaprine |
Sulfasalazine (sulphasalazine) |
Naproxen |
Amiodarone |
Cholestasis with mild hepatic component |
Phenothiazines |
Carbamazepine |
Tricyclic antidepressants |
Non‐steroidal anti‐inflammatory drugs (especially phenylbutazone) |
Rifampicin, ethambutol, pyrazinamide |
Sulphonylureas, trimethoprim |
Sulphonamides, ampicillin, nitrofurantoin, erythromycin estolate |
Oral contraceptives (stasis without hepatitis) |
Cirrhosis |
Methotrexate |