Читать книгу Clinical Pharmacology and Therapeutics - Группа авторов - Страница 78

Young children lack capacity to provide informed consent making trials of medicines in this age group ethically not possible. The majority of medicines available to children are unlicenced or their use is ‘off label’ (i.e. used for a purpose not indicated by the manufacturing label). Most paediatric units have developed their own guidelines and monographs for dosing, taking into account the factors discussed above. Valuable resources such as the BNF for Children are validated against available evidence, and are also helpful in the safe and appropriate management of diseases in childhood.