Читать книгу Clinical Pharmacology and Therapeutics - Группа авторов - Страница 74

A variety of factors influence pharmacokinetics in the young. Drug absorption may be affected by relatively high gastric pH in infants, and topical preparations are better absorbed because the skin is relatively thin. Low body fat content may reduce the volume of distribution of lipophilic drugs, and lower plasma albumin concentration reduces plasma protein binding. Immaturity of neonatal hepatic enzyme systems and renal excretion mechanisms may impair drug elimination, necessitating dosage reduction in the first months of life.