Читать книгу Biopolymers for Biomedical and Biotechnological Applications - Группа авторов - Страница 32

Hyaluronic acid (HA) is a linear polymer composed of repeating disaccharide units of glucuronic acid and N‐acetylglucosamine [130,131]. It is produced by S. zooepidemicus; however the concern about the pathogenicity of Streptococcus has driven the efforts toward transforming generally recognized as safe (GRAS) nonproducers (e.g. Lactococcus lactis, Bacillus subtilis) into HA producers [130]. HA shows a great swelling capacity, biocompatibility, non‐immunogenicity, biodegradability, and viscoelasticity. Its physicochemical and biological properties render HA potential for applications in cosmetics (e.g. dermal filler), pharmaceuticals, and medicine (e.g. osteoarthritis treatment, tissue engineering) [132,134]. Ongoing research on HA and its numerous modifications/blends shows the development of materials with improved properties for drug delivery and tissue engineering technologies [135,136].