Читать книгу Biopolymers for Biomedical and Biotechnological Applications - Группа авторов - Страница 42

Other microalgal EPS have shown direct antitumor and antiproliferative effect. Gymnodinium sp. EPS (GA3) promoted the apoptosis of human myeloid leukemia K562 cells by the inhibition of topoisomerases I and II [50]. Calcium spirulan of Arthrospira was reported to prevent pulmonary metastasis by inhibiting adhesion and proliferation of tumor cells [196]. EPSAH, an EPS produced by Aphanothece halophytica, induced apoptosis on the HeLa human cervical cancer cell line by targeting the protein regulator Grp78 that induces the loss of mitochondrial membrane potential and the p53–survivin pathway, resulting in caspase‐3 activation and causing apoptosis [55].