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2.5 Bionanocomposites Based on Microbial Polysaccharides

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MNPs are valuable nanostructures with proven applicability in areas such as molecular diagnostics and biomedicine [164,165]. Their unique physical properties can be tailored based on the size and composition of the inorganic material that can include noble metals (e.g. gold, silver), magnetic elements (e.g. iron, cobalt), or semiconductors (e.g. carbon nanotubes) [164]. The encapsulation of such MNPs in an inorganic (e.g. ceramic) or organic (e.g. biopolymeric) matrix generates multiphase materials (nanocomposites), wherein the synergetic effect between the components adds novel features to this material. Over the past years, the interest in the study and development of nanocomposites has grown considerably due to their valuable physical properties and countless applications that range from packaging to biomedicine [166].

Nanocomposites can have different types of matrices: ceramic, metallic, or polymeric. The properties and functionalities of these matrices can be enhanced by using diverse nanostructures such as ceramics, carbon nanotubes, metal nanoparticles, or even active biological substances [166]. Giving this, nowadays it is possible to produce nanocomposites for all sorts of applications. One good example is the production of a biocompatible hydrogel with conductive properties to be used in biomedicine. By using a polymer‐based matrix (e.g. chitosan) incorporated with a conductor inorganic material (e.g. carbon nanotubes), it is possible to produce a nanocomposite with potential use in the design of electrochemical biosensors [82,167]. Another great example is the nanocomposites produced with magnetic nanoparticles. These MNPs have their potentialities well established in the medical field. Usually, these applications take advantage of three unique features inherent to magnetic nanoparticles. These properties are the field‐induced mobility (for the development of drug delivery systems), their ability to modify magnetic relaxation times of surrounding molecules (for magnetic resonance imaging [MRI] applications), and their capacity to heat under an alternative magnetic field (for hyperthermia applications) [168,169]. The encapsulation of magnetic nanoparticles in a polymeric matrix (e.g. polyacrylamide) creates a thermoresponsive hydrogel. If this nanocomposite also contains a pharmaceutical drug, it could be used as a controlled release system. By applying an alternative magnetic field, the nanoparticles will increase their temperature changing the hydrogel structure to a more flexible state, allowing the easier delivery of the pharmaceutical substance [82]. In the previous examples, it has been established the importance of using polymeric matrices to produce nanomaterials with enhanced properties, as well as the potentialities of using these nanocomposites for medical applications.

More recently, it has been studied the use of biological polymers in the production of nanocomposites (bionanocomposites). The wide diversity of available natural polymers with distinct structures and properties has driven the interest toward the development of novel biopolymer nanocomposites with unique or improved functionalities. Unlike synthetic polymers, biopolymers have inherent favorable interaction with living systems [78]. Moreover, due to their chemical and structural diversity, biopolymers can provide excellent matrices for incorporation of different active substances (e.g. MNPs, hydrophilic and hydrophobic drugs), being more sustainable and having limited environmental impact due to their inherent biodegradability [80].

As previously mentioned, microbial polysaccharides have unique properties suitable to a wide range of applications. Some of these biopolymers are also known to have interactions with biological systems. These properties are usually associated with the composition of the polysaccharide. For instance, FucoPol is a biopolymer with potential antitumor and anti‐inflammatory properties due to its high fucose content. Fucose is a rare sugar with reported anticarcinogenic, antiaging, and anti‐inflammatory properties [4]. For these reasons, microbial polysaccharides can be used in the development of bionanocomposites not only as a matrix material due to their ability to form structured materials (e.g. hydrogels and films) but also as an active substance. This duality presented by the polysaccharides is an important feature for the development of bionanomaterials especially for biomedical applications [168,170].

Lately, the use of bionanocomposites with polysaccharides in several fields ranging from the degradation of pollutants to the development of hyperthermia agents and targeted delivery systems has been studied (Figure 2.4). For these types of applications, the biodegradability, the biocompatibility, and the biological response are important properties that can be easily attainable by using polysaccharides (especially from microbial origin) [172]. In Table 2.2, the use of distinct polysaccharides (all attainable through microbial production) and different MNPs for the development of nanocomposites for several applications has been shown. It is curious that the use of Au and Ag nanoparticles is usually associated with the production of nanocomposites with anticancer and antibacterial properties, respectively. Meanwhile, Fe3O4 nanoparticles are frequently related to the development of nanomaterials for drug delivery systems, hyperthermia, and contrast agents for MRI. Given this, the potentialities of the use of bionanocomposites with microbial polysaccharides especially in biomedicine remain well established.


Figure 2.4 Microbial polysaccharide‐based nanocomposites with metal nanoparticles for biotechnological applications.

Source: Adapted from Manivasagan and Oh 2016 [81] and Escárcega‐González et al. 2018 [171].

Table 2.2 Bionanocomposites containing polysaccharides and their applications.

Polysaccharide Nanoparticles Possible applications References
Hyaluronan Fe3O4 Contrast agents for MRI; drug delivery systems [169]
Dextran Fe3O4 Cellular MRI and fluorescence imaging; drug delivery systems [169]
Au0 Anticancer agent [171]
Ag0 Sensor for cysteine detection; antibacterial and antifungal agent [169]
Chitosan Fe3O4 Drug delivery systems [169]
Cu0/Fe0/CdS Degradation of Congo red and heavy metals in water (e.g. Cr(VI)) [170]
Fe3O4 Contrast agents for MRI; hyperthermia agent [168]
Xanthan gum Au0 Drug delivery systems; anticancer therapy [171]
Ag0 Antibacterial and catalytic agent [173]
Pd/Fe Soil remediation [171]
Gellan Gum Au0 Drug delivery systems; anticancer agent [171]
Ag0 Antibacterial and topical treatment
Fe3O4 Drug delivery systems; anticancer agent

MRI, magnetic resonance imaging.

Microbial polysaccharides show variability, versatility, stability, biocompatibility, and biodegradability. Adding to this, their important feature to act as a thickening, stabilizing, or binding agent makes them suitable to a wide range of applications, from food industry to pharmaceutical, medical, and cosmetic products. Moreover, since some of these biopolymers can form structured materials (such as gels and films), they could be used as matrices for the development of bionanocomposites with incorporated nanoparticles (Au0, Ag0, Fe3O4) for distinct applications in the biomedical field (anticancer, antibacterial, or hyperthermia agent, respectively). Polysaccharide‐based nanomaterials are an excellent source for nanotechnological applications in food, pharmaceutical, biomedicine, and cosmetic industries.

Biopolymers for Biomedical and Biotechnological Applications

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