Читать книгу Autoimmune Liver Disease - Группа авторов - Страница 77

Numerous studies indicate that miRNAs are important epigenetic regulators of proteins and networks involved in the generation and perpetuation of autoimmunity [17]. The mechanisms contributing to progressive autoimmunity include hyperactivation of innate macrophages and DCs, hyperstimulation of autoreactive T cells, inhibition of apoptotic elimination of autoreactive T and B cells, and alteration of regulatory balance. The impact of miRNAs alters the balance between pathogenic Th17 and iTregs by promoting dominance of Th17 cells.