Читать книгу Autoimmune Liver Disease - Группа авторов - Страница 79

Tissue‐resident memory T (T_RM) cells are a newly identified subset of non‐circulating antigen‐specific memory T cells that persist long term in epithelial barriers (e.g. skin, lung, gut and reproductive tract) and in brain, kidney, joints, and pancreas [25]. T_RM cells are distinct from circulating memory T cells and provide immediate protective responses upon reexposure to antigens. However, autoreactive T_RM cells have been implicated in chronic autoimmune diseases, including AIH, vitiligo, psoriasis, and RA. The longevity and privileged location of autoreactive T_RM cells within tissues favors perpetuation of autoinflammation and tissue destruction.