Читать книгу Autoimmune Liver Disease - Группа авторов - Страница 87

Ingestion of antigens leads to absorption and interaction with the reticuloendothelial system of the liver. Repeated ingestion can result in oral tolerance, defined as the inability to respond to the ingested antigen when given parenterally [29]. Low doses of antigen induce iTregs, while higher doses create anergic tolerance. Studies involving the induction of oral tolerance to glutamic acid decarboxylase, the instigating autoantigen in T1DM, are ongoing. The applicability of oral tolerance depends on identification of disease‐specific initiating autoantigens; thus, it would be currently relevant in AILDs only for PBC and type 2 AIH.