Читать книгу The SAGE Encyclopedia of Stem Cell Research - Группа авторов - Страница 404

Several trials have tested optimal techniques of SC administration. Some demonstrate that intravenous administration leads to SC-entrapment in the liver and lungs. Intracoronary infusion is the most frequently used technique; however, it is associated with only 1–3 percent myocardial retention. Direct intramyocardial injection of SCs has been shown to result in higher myocardial cell retention without compromising coronary flow. However, preclinical and clinical studies suggest that more than just cells are necessary to mend a diseased heart—the framework to support cells is also crucial. Without reestablishment of adequate cardiac vascularization and extracellular matrix, SCs are unlikely to survive. Future clinical trials plan to identify optimal SCs that permit treatment without immune suppression, optimal timing for chemoattraction of SC to damaged cardiac tissue, and optimal propagation in the myocardium.

Krishna S. Vyas

Tara Shrout

University of Kentucky College of Medicine

See Also: Heart: Cell Types Composing the Tissue; Heart: Current Research on Isolation or Production of Therapeutic Cells; Heart: Development and Regeneration Potential; Heart: Existing or Potential Regenerative Medicine Strategies; Heart: Major Pathologies; Heart: Stem and Progenitor Cells in Adults; Heart: Tissue Function; Heart Disease.