Читать книгу The SAGE Encyclopedia of Stem Cell Research - Группа авторов - Страница 410

Many clinical trials do not make it to actual clinical practice; one of the challenges faced by clinical researchers in the use of human stem cells is the difficulty in expanding the cell number to a usable quantity. Several studies have reported increased survival and efficiency in differentiation when larger numbers of stem cells are introduced to patients. The risk of donor-to-host infection, graft-versus-host diseases, and antigenic rejection occurring before transplanted stem cells initiate and maintain full blood cell production limits their clinical application in serious and fatal cases. On the other hand, the understanding and the knowledge of the conditions facilitating differentiation and plasticity of hematopoietic stem cells remains to be fully characterized. A better knowledge of stem cell biology will ultimately impact the usage of these cells in regular clinical practice.