Читать книгу The SAGE Encyclopedia of Stem Cell Research - Группа авторов - Страница 416

Though the use of a high-dose drug regime during transplantation of stem cells may reduce the problems associated with rejection and graft-versus-host disease, its use may have adverse fatal effects. Escalating doses of radiation therapy using helical tomotherapy in combination with fludarabine (FLU) and melphalan (MEL) as a preparative regimen for allogeneic hematopoietic stem cell transplantation in patients with advanced and hematological cancer who are not eligible for full myeloablative regimen may be beneficial. A phase I trial is investigating the side effects and best dose of total marrow and total lymph node irradiation. The trial seeks to test the maximum tolerable dose and intensity of modulated marrow and lymph node irradiation using tomotherapy. In addition, the toxicity, progression-free survival, and overall survival of this procedure is being tested. The frequency of acceptable clinical response, primary and secondary engraftment failure, time of neutrophil and platelet engraftment, and incidence of acute and chronic graft-versus-host disease will be studied in patients.