Читать книгу The SAGE Encyclopedia of Stem Cell Research - Группа авторов - Страница 415

Cord blood from unrelated donors is increasingly gaining the status of an alternative source of hematopoietic stem cells for adults with hematologic cancer who lack a human leukocyte-antigen (HLA)-matched donor. However, the utilization of single-unit cord blood for this purpose has been hampered by the low amount of nucleated cells in a single unit of cord blood. Researchers are looking at the potential of direct intrabone cord blood injection as a solution to the nucleated cell number problem, with the intention of minimizing nonspecific loss of progenitors. A phase I study and a phase II clinical trial are assessing the safety and efficacy of cord blood transplantation by intrabone cord blood injection in matured patients suffering from advanced or high-risk hematological cancer.